Because so little is known about the causes of dermographic urticaria, the therapeutic options are limited. All dermographic urticaria patients are first advised to avoid triggering stimulations as far as is possible. This includes avoidance of all tight, pinching and scouring clothing and tight belts. Dermographic urticaria patients should also avoid specific drugs, including fever-reducing pain medicines (acetylsalicylic acid, Diclofenac, Ibuprofen), penicillin and codeine, to whatever degree is possible. Only in rare cases can a cure be attempted by treating associated illnesses.
Modern antihistamines are usually an effective way of treating dermographic urticaria. The greatest problem is night-time occurrences of itchiness. In these cases, a lightly sedative antihistamine or a cream to sooth the itchiness can be used for the night. Other forms of therapy (such as drugs for suppressing the immune system) may be considered in individual cases, although accurate prognoses about the expected therapeutic success are rarely possible.